In other words, the positive health benefits associated with I3C are actually a result of its conversion to the more “bio-active” DIM. I3C itself remains inactive in the body, but after its conversion to DIM, it helps inhibit aromatase to decrease free-floating estradiol estrogen (E2) levels. I3C converts into DIM during digestion, which is then released into the bloodstream to work its magic on aromatase enzymes, SHBG-bound testosterone, and unmetabolized estrogen metabolites. The main reason: I3C works primarily as a precursor to DIM. Yet, despite their similarities, DIM is the preferred supplement choice over I3C. Indole-3-CarbinolĪs we already mentioned, DIM is derived from I3C–both being natural compounds found in Brassica vegetables both believed to reduce the risk factors associated with negative estrogen-influenced conditions. By Coyau / Wikimedia Commons, via Wikimedia Commons Diindolylmethane vs. Unfortunately, under certain circumstances, the opposite seems to also hold true. 2ĭuring an in-depth analysis of DIM’s metabolic and hormonal processes, researchers found that DIM might possess significant regulatory effects on testosterone & estrogen levels, potentially increasing active testosterone while reducing harmful, unmetabolized estrogens. Originally studied for its anti-inflammatory properties on respiratory inflammation, DIM was later found to have anti-viral and immune-boosting properties, which lead to DIM being clinically studied for the treatment and prevention of multiple forms of immune deficiency conditions and viral/bacterial infections. You know this species of vegetable through broccoli, but it also includes red cabbage, mustard greens, bok choy, horseradish, watercress, kale, and many others. 1ĭiindolylmethane (DIM) is the primary active metabolic compound derived from Indole-3 Carbinol (I3C), a chemical found in many vegetables of the Brassica family. DIM regulates levels of “bad” unmetabolized estrogen and “good” 2-hydroxy estrogen metabolites to help maintain healthy levels of active testosterone. DIM suppresses aromatase activity, protecting testosterone levels from depletion. Aromatase is an enzyme that converts testosterone to an estrogen. DIM releases “good” estrogen metabolites that bind to the same proteins testosterone uses, leaving more “free” testosterone available in the body. DIM may balance hormonal activity, contribute to better metabolism, and slightly increase free testosterone levels in the body. By Coyau / Wikimedia Commons, via Wikimedia CommonsĭIM is a plant-derived compound found in cruciferous vegetables like kale, broccoli, brussels sprouts, and cauliflower. Cruciferous phytochemical Diindolylmethane has anti-estrogen potential for women and might work for men, too.
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